Abstract: Structural lightweight design is an eternal theme in the development of aerospace, automotive, marine and other fields, and honeycomb aluminum sandwich panels are important component of lightweight structures. In this paper, a finite element model of three-point bending of honeycomb aluminum sandwich panels was established. Through the three-point bending finite element simulation analysis, the mechanical properties of honeycomb aluminum sandwich panel structures were studied. Influences of different panel thicknesses and different core layer thicknesses on the structural ultimate load were analyzed. The results show that the ultimate load-bearing capacity of honeycomb aluminum sandwich panel structures is positively correlated with both panel thickness and core layer thickness, and the change in core layer thickness has a greater impact on the ultimate load. The research results and conclusions obtained in this article provide a reference for the engineering application of honeycomb aluminum sandwich panel structures.