Abstract: This paper investigates the multi-axis orthogonal high-precision rotary frame, focusing on issues such as clamping difficulty, susceptibility to deformation, and excessive coaxiality errors. First, the precision requirements and machining challenges of structural components were analyzed, and by designing reasonable clamping methods and dedicated flexible fixtures, the machining of spherical and spatial fillets was accomplished. Next, in five-axis surface machining, the processing methods and toolpath strategies were analyzed to determine the surface machining process and relevant parameters. Surface patching was performed using UG software, and a T-shaped tool suitable for internal groove structures was designed. During roughing and finishing, auxiliary blank models were established to optimize cutting parameters, tool selection, and toolpath strategies. After generating the CAM CNC program, toolpath simulations were conducted to prevent collisions or interferences during machining. Finally, high-efficiency batch machining of thin-walled curved parts was achieved via five-axis CNC, ensuring the coaxiality of short-column long-distance components. Two heat treatment processes were implemented during machining, significantly enhancing the dimensional stability of the products.