Abstract: In order to solve the problems of low artificial seeding efficiency, difficult quantity control and difficult mechanized seeding of Astragalus membranaceus and other small particle size seeds of traditional Chinese medicine, a centrifugal pelleting device was designed. The device is composed of frame, powder supply system, shot host, automatic liquid adding unit, dust removal unit and electric control system. In order to explore the effect of the key technology of seed pelleting of traditional Chinese medicine on the quality of pellets, the contact mechanics analysis of seed pelleting process of traditional Chinese medicine was carried out. Through the discrete element edem simulation software, taking the rotation speed, powder feeding speed and centrifugal disc diameter as variables, box Behnken test was used and verified. The simulation test shows that the qualified rate of the device is 95.5% when the rotating speed of the centrifugal disc is 11.6 r/s, the powder feeding speed is 10.05 g/s, and the diameter of the centrifugal disc is 859 mm. At the same time, the actual test verification and germination rate test of the pelleting device were carried out. The actual results showed that the error between the simulation test and the actual test was less than 5%, and the simulation results had certain reference value, which could provide reference for the structure and process parameter optimization of the device.