Abstract: For the stamping liquid cooling battery box for energy storage, a CAE finite element simulation analysis and optimization design are conducted based on two typical working conditions: the static load bearing and the lifting. The results show that under the static load bearing condition, the area between the adjacent flow channels on both sides of the bottom of the liquid cooling plate are subjected to high stress, which exceeds the yield strength of the material, and the stress is relatively concentrated. Therefore, an optimization is proposed to increase the number of the convex hull structure on the surface of the bottom plate in order to provide more support. Under the lifting condition, the stress on the lifting hole area on the edge beams is relatively high, which is close to the yield strength of the material, so the strength of the lifting hole area is relatively weak. Therefore, the lifting method is adjusted by installing lifting frames on both sides of the upper cover. Through simulation verification, the optimizations show good performance, and the strength of the battery box is greatly improved, providing a reference for the design of the battery box structure and reliability.